PEDIATRICS Vol. 103 No. 5 Supplement May 1999, pp. 1085-1099
Children of Substance Abusers: Overview of Research Findings
Received Jan 4, 1999; accepted Jan 5, 1999.

From the * Department of Psychiatry, Division of Alcohol and
Drug Abuse, University of Maryland, Baltimore, Maryland; and the
Department of Psychiatry, Division of Child and Adolescent
Psychiatry, Johns Hopkins University, Baltimore, Maryland.
A relationship between parental substance abuse and subsequent alcohol problems in their children has been documented extensively. Children of alcoholics (COAs) are considered to be at high risk because there is a greater likelihood that they will develop alcoholism compared with a randomly selected child from the same community. COAs and children of other drug-abusing parents are especially vulnerable to the risk for maladaptive behavior because they have combinations of many risk factors present in their lives. The single most potent risk factor is their parent's substance-abusing behavior. This single risk factor can place children of substance abusers at biologic, psychologic, and environmental risk.
Since the turn of the century, many reports have described the deleterious influence of parental alcoholism on their children. A series of studies measured mortality, physiology, and general health in the offspring of alcoholic parents and concluded that when mothers stopped drinking during gestation, their children were healthier. Today, research on COAs can be classified into studies of fetal alcohol syndrome, the transmission of alcoholism, psychobiologic markers of vulnerability, and psychosocial characteristics. Each of these studies hypothesizes that differences between COAs and children of nonalcoholics influence maladaptive behaviors later in life, such as academic failure or alcoholism. This research supports the belief that COAs are at risk for a variety of problems that may include behavioral, psychologic, cognitive, or neuropsychologic deficits.
The vast literature on COAs far outweighs the literature on children of other drug abusers. Relatively little is known about children of heroin addicts, cocaine abusers, or polydrug abusers. Nonetheless, many researchers suggest that the children of addicted parents are at greater risk for later dysfunctional behaviors and that they, too, deserve significant attention to prevent intergenerational transmission of drug abuse. Most research on children of other drug abusers examines fetal exposure to maternal drug abuse.
The overview of the research on children of substance abusers points toward the need for better, longitudinal research in this area. Most studies on COAs or other drug abusers are not longitudinal; they examine behavior at one point in time. Given the studies reviewed in this article, it is unclear whether we see true deficits or developmental delay. Longitudinal studies will allow us to predict when early disorders and behavioral deviations will be transient or when they will be precursors to more severe types of maladaptive behavior. Longitudinal research also will enable us to explain specific childhood outcomes. Differences in outcome could be studied simultaneously to understand whether antecedents discovered for one are specific to it or are general antecedents leading to a broad variety of outcomes.
Key words: development, research, children of alcoholics, genetic, psychosocial.
This article has been cited by other articles:
![]() |
C. Osborne and L. M. Berger Parental Substance Abuse and Child Well-Being: A Consideration of Parents' Gender and Coresidence Journal of Family Issues, March 1, 2009; 30(3): 341 - 370. [Abstract] [PDF] |
||||
![]() |
B. Gance-Cleveland and M. Z. Mays School-Based Support Groups for Adolescents With a Substance-Abusing Parent Journal of the American Psychiatric Nurses Association, August 1, 2008; 14(4): 297 - 309. [Abstract] [PDF] |
||||
![]() |
P. Abate, M. Pueta, N. E. Spear, and J. C. Molina Fetal Learning About Ethanol and Later Ethanol Responsiveness: Evidence Against "Safe" Amounts of Prenatal Exposure Experimental Biology and Medicine, February 1, 2008; 233(2): 139 - 154. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Whitty and J. O'Connor Opiate dependence and pregnancy: 20-year follow-up study Psychiatr. Bull., December 1, 2007; 31(12): 450 - 453. [Abstract] [Full Text] [PDF] |
||||
![]() |
W. K. K. Lam, J. D. Cance, A. N. Eke, D. H. Fishbein, S. R. Hawkins, and J. Cassie Williams Children of African-American Mothers Who Use Crack Cocaine: Parenting Influences on Youth Substance Use J. Pediatr. Psychol., September 1, 2007; 32(8): 877 - 887. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. J. Vanderploeg, C. M. Connell, C. Caron, L. Saunders, K. H. Katz, and J. Kraemer Tebes The Impact of Parental Alcohol or Drug Removals on Foster Care Placement Experiences: A Matched Comparison Group Study Child Maltreat, May 1, 2007; 12(2): 125 - 136. [Abstract] [PDF] |
||||
![]() |
J. S. Brook, Y. Ning, E. B. Balka, D. W. Brook, E. H. Lubliner, and G. Rosenberg Grandmother and Parent Influences on Child Self-esteem Pediatrics, February 1, 2007; 119(2): e444 - e451. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. HANSSON, J. RUNDBERG, U. ZETTERLIND, K.O. JOHNSSON, and M. BERGLUND AN INTERVENTION PROGRAM FOR UNIVERSITY STUDENTS WHO HAVE PARENTS WITH ALCOHOL PROBLEMS: A RANDOMIZED CONTROLLED TRIAL Alcohol Alcohol., November 1, 2006; 41(6): 655 - 663. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. C. Whitaker, S. M. Orzol, and R. S. Kahn Maternal Mental Health, Substance Use, and Domestic Violence in the Year After Delivery and Subsequent Behavior Problems in Children at Age 3 Years. Arch Gen Psychiatry, May 1, 2006; 63(5): 551 - 560. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. CHALDER, F. J. ELGAR, and P. BENNETT DRINKING AND MOTIVATIONS TO DRINK AMONG ADOLESCENT CHILDREN OF PARENTS WITH ALCOHOL PROBLEMS Alcohol Alcohol., January 1, 2006; 41(1): 107 - 113. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. Day and S. George Management of drug misuse in pregnancy Adv. Psychiatr. Treat., July 1, 2005; 11(4): 253 - 261. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. J. Fraser Jr., G. N. McAbee, and Committee on Medical Liability Dealing With the Parent Whose Judgment Is Impaired by Alcohol or Drugs: Legal and Ethical Considerations Pediatrics, September 1, 2004; 114(3): 869 - 873. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. H. Claussen, K. G. Scott, P. C. Mundy, and L. F. Katz Effects of Three Levels of Early Intervention Services on Children Prenatally Exposed to Cocaine Journal of Early Intervention, April 1, 2004; 26(3): 204 - 220. [Abstract] [PDF] |
||||
![]() |
C. T. Mowbray, D. Bybee, D. Oyserman, P. Allen-Meares, P. Macfarlane, and T. Hart-Johnson Diversity of Outcomes Among Adolescent Children of Mothers With Mental Illness Journal of Emotional and Behavioral Disorders, January 1, 2004; 12(4): 206 - 221. [Abstract] [PDF] |
||||
![]() |
V. H. Accornero, C. E. Morrow, E. S. Bandstra, A. L. Johnson, and J. C. Anthony Behavioral Outcome of Preschoolers Exposed Prenatally to Cocaine: Role of Maternal Behavioral Health J. Pediatr. Psychol., April 1, 2002; 27(3): 259 - 269. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Keen, P. Oliver, G. Rowse, and N. Mathers Keeping families of heroin addicts together: results of 13 months' intake for community detoxification and rehabilitation at a family centre for drug users Fam. Pract., December 1, 2000; 17(6): 484 - 489. [Abstract] [Full Text] [PDF] |
||||

















