This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Eggert, P.
Right arrow Articles by Müller, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Eggert, P.
Right arrow Articles by Müller, D.
Related Collections
Right arrow Office Practice
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Facebook   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

PEDIATRICS Vol. 103 No. 2 February 1999, pp. 452-455

Regulation of Arginine Vasopressin in Enuretic Children Under Fluid Restriction

Received Mar 13, 1998; accepted Aug 6, 1998.

Paul Eggert*, Karen Müller-SchlüterDagger , and Dominik Müller*

From the * Klinik für Allgemeine Pädiatrie der Christian-Albrechts-Universität, Kiel, Germany; and Dagger  Kinderzentrum Bielefeld, Bielefeld, Germany.

Background.  Treatment of primary nocturnal enuresis using 1-deamino-8-D-arginine-vasopressin is based on the hypothesis that antidiuretic hormone (arginine vasopressin [AVP]) secretion is insufficient during the night. Persisting doubts about the theoretical background of this treatment and first results pointing to a different AVP regulation in children with nocturnal enuresis were the motives for the present study.

Objective.  To determine if children with primary nocturnal enuresis have different AVP levels during fluid restriction when compared with normal controls.

Methods.  Twenty-three children with nocturnal enuresis (median age, 11 years) were compared with a corresponding control group of 18 healthy children. Plasma osmolality, urine osmolality, and plasma AVP concentrations were determined before and after a defined fluid restriction.

Results.  Regarding plasma and urine osmolality, no differences were found between the two groups. AVP levels after fluid restriction, however, showed significant differences. To maintain osmolality, the plasma AVP concentrations of the controls rose to a median value of 5.7 pg/mL (range: 0.9-29.0 pg/mL) in comparison to a median of 14.0 pg/mL (range: 3.5-64.0 pg/mL, P = .015) for the enuretic children.

Conclusion.  The results are consistent with the established fact that AVP secretion is a function of plasma osmolality. They contradict the hypothesis that enuretic children have a AVP deficiency that has to be supplemented. Rather, the results point to a defect at the AVP receptor level or of the signal transduction pathway.  Key words:  nocturnal enuresis, AVP regulation, desmopressin treatment.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Facebook Facebook   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Am. J. Physiol. Renal Physiol.Home page
G. Valenti, A. Laera, S. Gouraud, G. Pace, G. Aceto, R. Penza, F. P. Selvaggi, and M. Svelto
Low-calcium diet in hypercalciuric enuretic children restores AQP2 excretion and improves clinical symptoms
Am J Physiol Renal Physiol, November 1, 2002; 283(5): F895 - F903.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
G. VALENTI, A. LAERA, G. PACE, G. ACETO, M. L. LOSPALLUTI, R. PENZA, F. P. SELVAGGI, M. L. CHIOZZA, and M. SVELTO
Urinary Aquaporin 2 and Calciuria Correlate with the Severity of Enuresis in Children
J. Am. Soc. Nephrol., October 1, 2000; 11(10): 1873 - 1881.
[Abstract] [Full Text]