PEDIATRICS Vol. 103 No. 1 January 1999, p. e10

ELECTRONIC ARTICLE:
Intractable Diarrhea From Cytomegalovirus Enterocolitis in an Immunocompetent Infant

Received Jun 26, 1998; accepted Aug 25, 1998.

LeAnne M. Fox^*, Michael A. Gerber, Laurie Penix^§, Andrew Ricci Jr, and Jeffrey S. Hyams

From the ^* University of Connecticut School of Medicine, University of Connecticut Health Center, Farmington, Connecticut;  Department of Pediatrics, University of Connecticut School of Medicine, Connecticut Children's Medical Center, Hartford, Connecticut; ^§ Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut; and  Department of Anatomic Pathology, Hartford Hospital, Hartford, Connecticut.

Infection with cytomegalovirus (CMV) in infants can be congenital or perinatal. Infected infants may be asymptomatic or present with pneumonia, rash, hepatosplenomegaly, or encephalitis.¹ In the presence of an immunodeficiency, severe and sometimes fatal disease may occur. To our knowledge, CMV has not been identified previously as a cause of intractable diarrhea of infancy. We report the case of a 5-week-old immunocompetent infant with intractable diarrhea attributable to CMV-induced enterocolitis. Recognition of this infection and initiation of ganciclovir therapy was associated with a rapid improvement and resolution of the diarrhea.

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