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PEDIATRICS Vol. 102 No. 6 December 1998, p. e73

ELECTRONIC ARTICLE:
Involution Rate of Multicystic Renal Dysplasia

Received Jul 22, 1997; accepted May 28, 1998.

Oded J. Kessler*, Niza Ziv§, Pinchas M. Livne*, and P. Merlob§

From the Departments of * Urology, Dagger  Neonatology and § Radiology, Schneider Children's Medical Center of Israel, Beilinson Campus, Petah Tiqva; and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Objective.  To document the involution rate and long-term results of management of multicystic dysplastic kidney.

Materials and Methods.  Data were collected retrospectively for all 23 infants (16 boys) with multicystic dysplastic kidney who were treated at our center over the last 19 years (1977-1995). The diagnosis was based on prenatal ultrasound in 18 patients and on palpable abdominal mass in 5, and confirmed in all patients by postnatal ultrasound and radioisotope scan. Voiding cystography was performed in 18 patients to exclude vesicoureteral reflux. Mean follow-up was 46 months (range, 3 months to 5 years) and included serum creatinine measurements and renal ultrasonography.

Results.  Two groups of patients were identified. Ten (43.6%) with other urologic abnormalities (group A) and 13 patients without other urologic abnormalities (group B). Vesicoureteral reflux was observed in 4 patients. Nephrectomy was performed in 4 patients, all from group B. The other 19 patients were treated conservatively. Complete involution was observed in 8 patients in group A and 6 in group B after a mean follow-up period of 9.2 and 10 months, respectively. Two patients, 1 from each group, later underwent nephrectomy not because of no involution but because of an increase in the size of the kidney involved.

Conclusion.  Patients with multicystic renal dysplasia have significant associated urologic malformations, and the natural history of the disease is unpredictable. All patients require appropriate investigation of the urinary tract and long-term follow-up. The most outstanding finding of the study is the much higher involution rate of multicystic renal dysplasia and the rate of associated urologic abnormalities than that reported in the literature. Surgery remains an option for the patients in the absence of no involution. multicystic dysplastic kidney, surgery, conservative. .


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