This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Related Collections
Right arrow Infectious Disease & Immunity

PEDIATRICS Vol. 102 No. 6 December 1998, pp. 1483-1491

AMERICAN ACADEMY OF PEDIATRICS:
Prevention of Rotavirus Disease: Guidelines for Use of Rotavirus Vaccine

Committee on Infectious Diseases

Virtually all children experience rotavirus (Rv) infection before school entry. In the United States and other temperate countries, Rv disease peaks in the winter and during this time is responsible for the majority of episodes of diarrhea in infants and young children.1-4 Data collected by the Centers for Disease Control and Prevention from 1979 through 1992 indicate that approximately 50 000 hospitalizations attributable to Rv occur annually in the United States, a number that approximates about 1 in 78 children being hospitalized with Rv diarrhea by 5 years of age.2,5

RotaShield (Wyeth-Lederle Vaccines and Pediatrics, Philadelphia, PA) was licensed by the Food and Drug Administration on August 31, 1998, for oral administration to infants at 2, 4, and 6 months of age. The rationale for using Rv immunization for prevention or modification of Rv disease is based on several considerations. First, the rate of illness attributable to Rv among children is comparable in industrialized and developing countries, which indicates that improved public sanitation is unlikely to decrease the incidence of disease.6,7 Second, although implementation of oral rehydration programs to prevent dehydration has improved in the United States, widespread use is inadequate to prevent significant morbidity.8-11 Third, trials of rhesus rotavirus-tetravalent (Rv) vaccine in the United States, Finland, and Venezuela show efficacy rates of approximately 80% for prevention of severe illness and 48% to 68% against Rv-induced diarrheal episodes.12-16 These results are similar to the protection observed after natural Rv infection, which also confers better protection against subsequent episodes of severe disease than against mild illness.17-19 This statement provides recommendations regarding the use of Rv vaccine in infants in the United States.

.


The following policy statement is a revision:

Prevention of Rotavirus Disease: Guidelines for Use of Rotavirus Vaccine

Pediatrics 119: 171-182. [Full Text]



This article has been cited by other articles:


Home page
 cfpHome page
S. M. Moss
Emerging vaccines: Evidence and considerations for practice integration
Can Fam Physician, December 1, 2007; 53(12): 2150 - 2156.
[Full Text] [PDF]

Home page
 PediatricsHome page
A. Kempe, M. F. Daley, U. D. Parashar, L. A. Crane, B. L. Beaty, S. Stokley, J. Barrow, C. Babbel, L. M. Dickinson, M.-A. Widdowson, et al.
Will Pediatricians Adopt the New Rotavirus Vaccine?
Pediatrics, January 1, 2007; 119(1): 1 - 10.
[Abstract] [Full Text] [PDF]

Home page
 CLIN PEDIATRHome page
Y. Y. Lee, R. Lee, and L. G. Yamamoto
Intussusception Incidence Relative to Rotavirus Vaccine Use in Honolulu
Clinical Pediatrics, November 1, 2005; 44(9): 791 - 795.
[Abstract] [PDF]

Home page
 J. Virol.Home page
N. Parez, A. Garbarg-Chenon, C. Fourgeux, F. Le Deist, A. Servant-Delmas, A. Charpilienne, J. Cohen, and I. Schwartz-Cornil
The VP6 Protein of Rotavirus Interacts with a Large Fraction of Human Naive B Cells via Surface Immunoglobulins
J. Virol., November 15, 2004; 78(22): 12489 - 12496.
[Abstract] [Full Text] [PDF]

Home page
 J. Gen. Virol.Home page
H. Qiao, H. F. Clark, M. DiVietro, and M. Riepenhoff-Talty
A comparison of the effects of oral inoculation with Rotashield and pentavalent reassortant rotavirus vaccine (WC3-PV) on suckling CB17scid mice
J. Gen. Virol., August 1, 2004; 85(8): 2245 - 2253.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
P. Haber, R. T. Chen, L. R. Zanardi, G. T. Mootrey, R. English, M. M. Braun, and the VAERS Working Group
An Analysis of Rotavirus Vaccine Reports to the Vaccine Adverse Event Reporting System: More Than Intussusception Alone?
Pediatrics, April 1, 2004; 113(4): e353 - e359.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
M. Iwamoto, T. N. Saari, S. R. McMahon, H. R. Yusuf, M. S. Massoudi, J. M. Stevenson, S. Y. Chu, and L. K. Pickering
A Survey of Pediatricians on the Reintroduction of a Rotavirus Vaccine
Pediatrics, July 1, 2003; 112(1): e6 - 10.
[Abstract] [Full Text] [PDF]

Home page
 Am J EpidemiolHome page
S. Perez Mato, K. Perrin, D. Scardino, and R. E. Begue
Evaluation of Rotavirus Vaccine Effectiveness in a Pediatric Group Practice
Am. J. Epidemiol., December 1, 2002; 156(11): 1049 - 1055.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
G. Peter and M. G. Myers
Intussusception, Rotavirus, and Oral Vaccines: Summary of a Workshop
Pediatrics, December 1, 2002; 110(6): e67 - 67.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
M. C. Danovaro-Holliday, A. L. Wood, and C. W. LeBaron
Rotavirus Vaccine and the News Media, 1987-2001
JAMA, March 20, 2002; 287(11): 1455 - 1462.
[Abstract] [Full Text] [PDF]

Home page
 Am J EpidemiolHome page
S. L. Sansom, L. Barker, P. S. Corso, C. Brown, and R. Deuson
Rotavirus Vaccine and Intussusception: How Much Risk Will Parents in the United States Accept to Obtain Vaccine Benefits?
Am. J. Epidemiol., December 1, 2001; 154(11): 1077 - 1085.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Microbiol. Rev.Home page
P. H. Dennehy
Active Immunization in the United States: Developments over the Past Decade
Clin. Microbiol. Rev., October 1, 2001; 14(4): 872 - 908.
[Abstract] [Full Text] [PDF]

Home page
 Arch Pediatr Adolesc MedHome page
H. A. McPhillips, R. L. Davis, E. K. Marcuse, and J. A. Taylor
The Rotavirus Vaccine's Withdrawal and Physicians' Trust in Vaccine Safety Mechanisms
Arch Pediatr Adolesc Med, September 1, 2001; 155(9): 1051 - 1056.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
H.-G. H. Chang, P. F. Smith, J. Ackelsberg, D. L. Morse, and R. I. Glass
Intussusception, Rotavirus Diarrhea, and Rotavirus Vaccine Use Among Children in New York State
Pediatrics, July 1, 2001; 108(1): 54 - 60.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
J. W. Gobel;, M. Rennels, J. Abramson, and J. Modlin
The Rotavirus Vaccine Story
Pediatrics, July 1, 2001; 108(1): 220 - 220.
[Full Text]

Home page
 PediatricsHome page
L. R. Zanardi, P. Haber, G. T. Mootrey, M. T. Niu, M. Wharton, and the VAERS Working Group
Intussusception Among Recipients of Rotavirus Vaccine: Reports to the Vaccine Adverse Event Reporting System
Pediatrics, June 1, 2001; 107(6): e97 - 97.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
T. V. Murphy, P. M. Gargiullo, M. S. Massoudi, D. B. Nelson, A. O. Jumaan, C. A. Okoro, L. R. Zanardi, S. Setia, E. Fair, C. W. LeBaron, et al.
Intussusception among Infants Given an Oral Rotavirus Vaccine
N. Engl. J. Med., February 22, 2001; 344(8): 564 - 572.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
U. D. Parashar, R. C. Holman, K. C. Cummings, N. W. Staggs, A. T. Curns, C. M. Zimmerman, S. F. Kaufman, J. E. Lewis, D. J. Vugia, K. E. Powell, et al.
Trends in Intussusception-Associated Hospitalizations and Deaths Among US Infants
Pediatrics, December 1, 2000; 106(6): 1413 - 1421.
[Abstract] [Full Text]

Home page
 Arch Pediatr Adolesc MedHome page
E. L. Ford-Jones, E. Wang, M. Petric, P. Corey, R. Moineddin, M. Fearon, and for The Greater Toronto Area/Peel Region PRESI Stu
Hospitalization for Community-Acquired, Rotavirus-Associated Diarrhea: A Prospective, Longitudinal, Population-Based Study During the Seasonal Outbreak
Arch Pediatr Adolesc Med, June 1, 2000; 154(6): 578 - 585.
[Abstract] [Full Text] [PDF]

Home page
 Arch Pediatr Adolesc MedHome page
E. L. Ford-Jones, E. Wang, M. Petric, P. Corey, R. Moineddin, M. Fearon, and for The Greater Toronto Area/Peel Region PRESI Stu
Rotavirus-Associated Diarrhea in Outpatient Settings and Child Care Centers
Arch Pediatr Adolesc Med, June 1, 2000; 154(6): 586 - 593.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
R. Srivastava, H. M. Zinman, M. D. McKenzie, P. J. Curran, D. A. Landis, M. A. Blumenthal, M. P. Kelliher, S. L. Hamewey;, J. S. Abramson, and L. K. Pickering
Rotavirus Vaccine
Pediatrics, December 1, 1999; 104(6): 1419 - 1420.
[Full Text]

Home page
 PediatricsHome page
U. D. Parashar, M. A. Chung, R. C. Holman, R. W. Ryder, J. L. Hadler, and R. I. Glass
Use of State Hospital Discharge Data to Assess the Morbidity From Rotavirus Diarrhea and to Monitor the Impact of a Rotavirus Immunization Program: A Pilot Study in Connecticut
Pediatrics, September 1, 1999; 104(3): 489 - 494.
[Abstract] [Full Text] [PDF]

Home page
 Arch. Dis. Child.Home page
M. RAMSAY
Rotavirus: a new vaccine for the UK?
Arch. Dis. Child., August 1, 1999; 81(2): 101 - 102.
[Full Text]

Home page
 J. Clin. Microbiol.Home page
L. E. Unicomb, G. Podder, J. R. Gentsch, P. A. Woods, K. Z. Hasan, A. S. G. Faruque, M. J. Albert, and R. I. Glass
Evidence of High-Frequency Genomic Reassortment of Group A Rotavirus Strains in Bangladesh: Emergence of Type G9 in 1995
J. Clin. Microbiol., June 1, 1999; 37(6): 1885 - 1891.
[Abstract] [Full Text]

Home page
 Pediatr. Rev.Home page
G. Kuo and T. L. Cheng
Rotavirus Infections
Pediatr. Rev., February 1, 1999; 20(2): 70 - 70.
[Full Text]

Home page
 PediatricsHome page
Committee on Infectious Diseases
Recommended Childhood Immunization Schedule---United States, January-December 1999
Pediatrics, January 1, 1999; 103(1): 182 - 185.
[Full Text] [PDF]