This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kern, J. H.
Right arrow Articles by Gersony, W. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kern, J. H.
Right arrow Articles by Gersony, W. M.
Related Collections
Right arrow Heart & Blood Vessels

PEDIATRICS Vol. 102 No. 5 November 1998, pp. 1148-1152

Early Developmental Outcome After the Norwood Procedure for Hypoplastic Left Heart Syndrome

Received Feb 3, 1998; accepted Apr 23, 1998.

Jeffrey H. Kern*, Veronica J. HintonDagger , Nancy E. NereoDagger , Constance J. Hayes*, and Welton M. Gersony*

From the * Columbia-Presbyterian Medical Center, Department of Pediatrics; and the Dagger  GH Sergievsky Center and Department of Neurology, Columbia University College of Physicians and Surgeons, New York, New York.

Objective.  To assess intellect and adaptive behavior in children with hypoplastic left heart syndrome (HLHS) who had undergone at least two surgical stages of the Norwood procedure.

Methods.  Fourteen children with HLHS >3 years of age participated in the study. The patients underwent intelligence quotient (IQ) testing, and their parents were interviewed regarding their children's adaptive behavior. Results were compared with those of 10 family controls. Outcomes were studied for possible correlation with perioperative variables.

Results.  Among the HLHS patients, the median scores for full scale IQ and adaptive behavior were 88 and 91, respectively (normal = 100 ± 15). One child met criteria for mental retardation. Family controls scored generally higher than did HLHS patients, but only differences in adaptive behavior were statistically significant. A negative correlation was found between stage I circulatory arrest time and full scale IQ.

Conclusions.  Children with HLHS most often function in the low-normal range of intelligence and adaptive behavior. A prolonged circulatory arrest time may result in decreased intellectual function.  Key words:  congenital heart disease, cardiac surgery, neurodevelopment.




This article has been cited by other articles:


Home page
 CirculationHome page
J. Atallah, I. A. Dinu, A. R. Joffe, C. M.T. Robertson, R. S. Sauve, J. D. Dyck, D. B. Ross, I. M. Rebeyka, and the Western Canadian Complex Pediatric Therapies F
Two-Year Survival and Mental and Psychomotor Outcomes After the Norwood Procedure: An Analysis of the Modified Blalock-Taussig Shunt and Right Ventricle-to-Pulmonary Artery Shunt Surgical Eras
Circulation, September 30, 2008; 118(14): 1410 - 1418.
[Abstract] [Full Text] [PDF]

Home page
 Arch Pediatr Adolesc MedHome page
G. Wernovsky
The Paradigm Shift Toward Surgical Intervention for Neonates With Hypoplastic Left Heart Syndrome
Arch Pediatr Adolesc Med, September 1, 2008; 162(9): 849 - 854.
[Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
G. Wernovsky
Improving neurologic and quality-of-life outcomes in children with congenital heart disease: Past, present, and future
J. Thorac. Cardiovasc. Surg., February 1, 2008; 135(2): 240 - 242.
[Full Text] [PDF]

Home page
 Qual Health ResHome page
G. R. Rempel and M. J. Harrison
Safeguarding Precarious Survival: Parenting Children Who Have Life-Threatening Heart Disease
Qual Health Res, July 1, 2007; 17(6): 824 - 837.
[Abstract] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
A. Sarajuuri, E. Jokinen, R. Puosi, M. Eronen, L. Mildh, I. Mattila, L. Valanne, and T. Lonnqvist
Neurodevelopmental and neuroradiologic outcomes in patients with univentricular heart aged 5 to 7 years: Related risk factor analysis
J. Thorac. Cardiovasc. Surg., June 1, 2007; 133(6): 1524 - 1532.
[Abstract] [Full Text] [PDF]

Home page
 J Pediatr PsycholHome page
P. A. Karsdorp, W. Everaerd, M. Kindt, and B. J.M. Mulder
Psychological and Cognitive Functioning in Children and Adolescents with Congenital Heart Disease: A Meta-Analysis
J. Pediatr. Psychol., June 1, 2007; 32(5): 527 - 541.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
C. S. Goldberg, E. L. Bove, E. J. Devaney, E. Mollen, E. Schwartz, S. Tindall, C. Nowak, J. Charpie, M. B. Brown, T. J. Kulik, et al.
A randomized clinical trial of regional cerebral perfusion versus deep hypothermic circulatory arrest: Outcomes for infants with functional single ventricle
J. Thorac. Cardiovasc. Surg., April 1, 2007; 133(4): 880 - 887.
[Abstract] [Full Text] [PDF]

Home page
 ICVTSHome page
S. T. Hussain, A. Bhan, S. Sapra, R. Juneja, S. Das, and S. Sharma
The bidirectional cavopulmonary (Glenn) shunt without cardiopulmonary bypass: is it a safe option?
Interactive CardioVascular and Thoracic Surgery, February 1, 2007; 6(1): 77 - 82.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
K. J. Visconti, D. Rimmer, K. Gauvreau, P. del Nido, J. E. Mayer Jr, I. Hagino, and F. A. Pigula
Regional Low-Flow Perfusion Versus Circulatory Arrest in Neonates: One-Year Neurodevelopmental Outcome
Ann. Thorac. Surg., December 1, 2006; 82(6): 2207 - 2213.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
C. L. Dent, J. P. Spaeth, B. V. Jones, S. M. Schwartz, T. A. Glauser, B. Hallinan, J. M. Pearl, P. R. Khoury, and C. D. Kurth
Brain magnetic resonance imaging abnormalities after the Norwood procedure using regional cerebral perfusion
J. Thorac. Cardiovasc. Surg., January 1, 2006; 131(1): 190 - 197.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
W. T. Mahle, K. J. Visconti, M. C. Freier, S. M. Kanne, W. G. Hamilton, A. M. Sharkey, R. E. Chinnock, K. J. Jenkins, P. K. Isquith, T. G. Burns, et al.
Relationship of Surgical Approach to Neurodevelopmental Outcomes in Hypoplastic Left Heart Syndrome
Pediatrics, January 1, 2006; 117(1): e90 - e97.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
C. L. Dent, J. P. Spaeth, B. V. Jones, S. M. Schwartz, T. A. Glauser, B. Hallinan, J. M. Pearl, P. R. Khoury, and C. D. Kurth
Brain magnetic resonance imaging abnormalities after the Norwood procedure using regional cerebral perfusion
J. Thorac. Cardiovasc. Surg., December 1, 2005; 130(6): 1523 - 1530.
[Abstract] [Full Text] [PDF]

Home page
 Crit Care NurseHome page
D. Soetenga and K. A. Mussatto
Management of Infants With Hypoplastic Left Heart Syndrome: Integrating Research Into Nursing Practice
Crit. Care Nurse, December 1, 2004; 24(6): 46 - 66.
[Full Text] [PDF]

Home page
 PediatricsHome page
J. A. Connor, R. R. Arons, M. Figueroa, and K. M. Gebbie
Clinical Outcomes and Secondary Diagnoses for Infants Born With Hypoplastic Left Heart Syndrome
Pediatrics, August 1, 2004; 114(2): e160 - e165.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
R. M. Ungerleider, I. Shen, T. Yeh Jr, J. Schultz, R. Butler, M. Silberbach, C. Giacomuzzi, E. Heller, L. Studenberg, B. Mejak, et al.
Routine mechanical ventricular assist following the Norwood procedure--improved neurologic outcome and excellent hospital survival
Ann. Thorac. Surg., January 1, 2004; 77(1): 18 - 22.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
T. R. Karl, S. Hall, G. Ford, E. A. Kelly, C. P. R. Brizard, R. B. B. Mee, R. G. Weintraub, A. D. Cochrane, and D. Glidden
Arterial switch with full-flow cardiopulmonary bypass and limited circulatory arrest: Neurodevelopmental outcome
J. Thorac. Cardiovasc. Surg., January 1, 2004; 127(1): 213 - 222.
[Abstract] [Full Text]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
D. Wypij, J. W. Newburger, L. A. Rappaport, A. J. duPlessis, R. A. Jonas, G. Wernovsky, M. Lin, and D. C. Bellinger
The effect of duration of deep hypothermic circulatory arrest in infant heart surgery on late neurodevelopment: The Boston Circulatory Arrest Trial
J. Thorac. Cardiovasc. Surg., November 1, 2003; 126(5): 1397 - 1403.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
J. M. Pearl, D. P. Nelson, S. M. Schwartz, and P. B. Manning
First-stage palliation for hypoplastic left heart syndrome in the twenty-first century
Ann. Thorac. Surg., January 1, 2002; 73(1): 331 - 339.
[Abstract] [Full Text] [PDF]

Home page
 CLIN PEDIATRHome page
S. Weinberg, J. Kern, K. Weiss, and G. Ross
Developmental Screening of Children Diagnosed with Congenital Heart Defects
Clinical Pediatrics, September 1, 2001; 40(9): 497 - 501.
[Abstract] [PDF]

Home page
 J Child NeurolHome page
C. Limperopoulos, A. Majnemer, B. Rosenblatt, M. I. Shevell, C. Rohlicek, C. Tchervenkov, and R. Gottesman
Association Between Electroencephalographic Findings and Neurologic Status in Infants With Congenital Heart Defects
J Child Neurol, July 1, 2001; 16(7): 471 - 476.
[Abstract] [PDF]

Home page
 PediatricsHome page
R. R. Clancy, S. A. McGaurn, J. E. Goin, D. G. Hirtz, W. I. Norwood, J. W. Gaynor, M. L. Jacobs, G. Wernovsky, W. T. Mahle, J. D. Murphy, et al.
Allopurinol Neurocardiac Protection Trial in Infants Undergoing Heart Surgery Using Deep Hypothermic Circulatory Arrest
Pediatrics, July 1, 2001; 108(1): 61 - 70.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
W. T. Mahle, R. R. Clancy, S. P. McGaurn, J. E. Goin, and B. J. Clark
Impact of Prenatal Diagnosis on Survival and Early Neurologic Morbidity in Neonates With the Hypoplastic Left Heart Syndrome
Pediatrics, June 1, 2001; 107(6): 1277 - 1282.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
P. M. Verheijen, L. A. Lisowski, P. Stoutenbeek, J. F. Hitchcock, J. I. Brenner, J. A. Copel, C. S. Kleinman, E. J. Meijboom, and G. B. W. E. Bennink
Prenatal diagnosis of congenital heart disease affects preoperative acidosis in the newborn patient
J. Thorac. Cardiovasc. Surg., April 1, 2001; 121(4): 798 - 803.
[Abstract] [Full Text] [PDF]

Home page
 SEMIN CARDIOTHORAC VASC ANESTHHome page
S. Tebich
How Does One Safely Anesthetize a Univentricular Patient for Noncardiac Surgery?
Seminars in Cardiothoracic and Vascular Anesthesia, March 1, 2001; 5(1): 40 - 45.
[Abstract] [PDF]

Home page
 CirculationHome page
G. Wernovsky, K. M. Stiles, K. Gauvreau, T. L. Gentles, A. J. duPlessis, D. C. Bellinger, A. Z. Walsh, J. Burnett, R. A. Jonas, J. E. Mayer Jr, et al.
Cognitive Development After the Fontan Operation
Circulation, August 22, 2000; 102(8): 883 - 889.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
W. T. Mahle, R. R. Clancy, E. M. Moss, M. Gerdes, D. R. Jobes, and G. Wernovsky
Neurodevelopmental Outcome and Lifestyle Assessment in School-Aged and Adolescent Children With Hypoplastic Left Heart Syndrome
Pediatrics, May 1, 2000; 105(5): 1082 - 1089.
[Abstract] [Full Text]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
D. L. Williams, A. C. Gelijns, A. J. Moskowitz, A. D. Weinberg, J. H. Ng, E. Crawford, C. J. Hayes, and J. M. Quaegebeur
HYPOPLASTIC LEFT HEART SYNDROME: VALUING THE SURVIVAL
J. Thorac. Cardiovasc. Surg., April 1, 2000; 119(4): 720 - 731.
[Abstract] [Full Text] [PDF]