This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tayaba, R.
Right arrow Articles by Holzman, I. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tayaba, R.
Right arrow Articles by Holzman, I. R.
Related Collections
Right arrow Premature & Newborn
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Facebook   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

PEDIATRICS Vol. 102 No. 3 September 1998, p. e28

ELECTRONIC ARTICLE:
Noninvasive Estimation of Serum Bilirubin

Received Feb 13, 1998; accepted April 29, 1998.

Roland TayabaDagger , Donald Gribetz*, Irwin Gribetz*, and Ian R. Holzman*

From the * Department of Pediatrics, Mount Sinai School of Medicine, New York, New York, and the Dagger  Department of Pediatrics, City Hospital Center at Elmhurst, Queens, New York.

Objective.  The aim of this study was to evaluate the accuracy and clinical usefulness of a new computer-driven, hand-held device (Chromatics Colormate III) to estimate serum bilirubin from skin-reflectance (skin color) of neonates.

Study Design.  A total of 2441 infants (both term and premature) at two hospitals had repeated measurements of transcutaneous bilirubin. Of these infants, 900 had one or more laboratory determinations of serum bilirubin. Many of the infants had early measurements of skin color before the onset of jaundice. A visual estimate of the degree of jaundice was made by a health care worker when the laboratory study was drawn. A subgroup of 61 infants was also studied while undergoing phototherapy with a total of 284 comparisons obtained. The reproducibility of the instrument was assessed separately using standardized color tiles and repeated measurements by multiple operators.

Results.  The range of serum bilirubin measurements that had concurrent skin color measurements was 3.22 to 338.1 µmol/L (0.2 to 21 mg/dL). The linear regression indicated an r = 0.956, and 95% of the skin color measurements were within 32.2 µmol/L (2.0 mg/dL). There was no interference with the accuracy of the device because of infant race or weight, or because of the use of phototherapy. The device provided reproducible information when infants were tested repeatedly over 30 minutes; the coefficient of variation for the transcutaneous bilirubin measurement was 3.1% around a mean estimate of 135.32 µmol/L (8.4 mg/dL).

Conclusion.  The Chromatics Colormate III allows for a clinically useful estimate of serum bilirubin in a wide variety of infants. By using a color discrimination algorithm and obtaining a skin measurement before the onset of icterus, this instrument can provide valuable clinical information that obviates the need for serum bilirubin determinations. Its use in newborn nurseries may allow physicians to shorten length of stay more safely and decrease the use of invasive blood tests.  Key words:  jaundice, newborn, transcutaneous.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Facebook Facebook   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Clin. Chem.Home page
S. N. El-Beshbishi, K. E. Shattuck, A. A. Mohammad, and J. R. Petersen
Hyperbilirubinemia and Transcutaneous Bilirubinometry
Clin. Chem., July 1, 2009; 55(7): 1280 - 1287.
[Abstract] [Full Text] [PDF]

Home page
 J Am Board Fam MedHome page
K. B. Kolman, K. M. Mathieson, and C. Frias
A Comparison of Transcutaneous and Total Serum Bilirubin in Newborn Hispanic Infants at 35 or More Weeks of Gestation
J Am Board Fam Med, May 1, 2007; 20(3): 266 - 271.
[Abstract] [Full Text] [PDF]

Home page
 NeoReviewsHome page
M. J. Maisels
Historical Perspectives: Transcutaneous Bilirubinometry
NeoReviews, May 1, 2006; 7(5): e217 - e225.
[Full Text] [PDF]