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PEDIATRICS Vol. 102 No. 1 Supplement July 1998, pp. 231-233

COMMENTARY:
Isolation of the Respiratory Syncytial Virus From a Patient With Pneumonia, by Daniel S. Rowe, MD, and Richard H. Michaels, MD, Pediatrics, 1960;26:623-629

Received Mar 19, 1998; accepted Mar 19, 1998.

Comments by W. Paul Glezen

From the Departments of Microbiology and Immunology, and Pediatrics, Baylor College of Medicine, Houston, Texas.

A virus with the characteristics of the respiratory syncytial virus was isolated from the throat of a 6-month-old infant with pneumonia. The illness was accompanied by an eightfold increase in complement-fixation antibody to the Long strain of the respiratory syncytial virus identified by Chanock and colleagues and a 16-fold rise in the homologous neutralizing antibody, indicating that the pneumonia was accompanied by infection with this virus. The virus was labile to freezing at -15 to -20°C; isolation was possible from the original unfrozen specimen inoculated immediately or from passage virus pools sealed in glass ampules and stored in the dry ice chest.


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