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PEDIATRICS Vol. 102 No. 1 Supplement July 1998, pp. 207-209

COMMENTARY:
Humoral Antibody Formation in Infants Aged One to Three Months Injected With a Triple (Diphtheria-Tetanus-Pertussis) Alum-precipitated Antigen, by William L. Bradford, MD, et al, Pediatrics, 1949;4:711-718

Received Mar 19, 1998; accepted Mar 19, 1998.

Comments by Samuel Lawrence Katz

From the Department of Pediatrics, Duke University Medical Center, Durham, North Carolina.

Infants 1 to 3 months of age were immunized with a vaccine combining diphtheria and tetanus toxoids with pertussis organisms. The combination product was adjuvanted with alum. Infants were injected at four-week intervals between 1-3 months of age and boosted at 7-9 months of age. Serum antibody determinations were done 3 months after completion of the initial three administrations; again at 7-9 months of age, 6 months after completion of the original course; and a booster injection was given and final determinations obtained on serum collected at eight to ten months of age. Utilizing a variety of antitoxin and agglutination techniques, more than 90% of infants had effective antitoxin levels against diphtheria and tetanus on all three laboratory determinations whereas only 53% at 3 months, 51% at 6 months and 80% at 10 months had titers judged protective vs pertussis. It was therefore demonstrated that infants at this young age could respond satisfactorily with humoral antibodies against both diphtheria and tetanus toxoids but less so against pertussis.


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