PEDIATRICS Vol. 101 No. 4 April 1998, pp. 597-603
Three-year Follow-up of Vaccine Response in Extremely Preterm Infants
Received Apr 17, 1997; accepted Sep 8, 1997.
, and
From the * Department of Pediatrics, Neonatology, Strong
Children's Research Center, Rochester, New York; and the Department
of Microbiology and Immunology, University of Rochester, Rochester, New
York.
Objective. To assess whether the adequate antibody response observed in former extremely premature infants after the primary series of immunizations is sustained after the first booster vaccines.
Subjects and Methods. Sixteen former extremely premature (<29 weeks, <1000 g at birth) and 17 former full-term (>37 weeks) infants had sera obtained for antibody titer measurement at 3 to 4 years of age. All had received the primary series and first booster vaccines for diphtheria, pertussis, tetanus, polio, and Haemophilus influenzae type b. Twelve preterm and 14 full-term children had completed the hepatitis B vaccine series.
Results. At 3 to 4 years of age, former preterm and
full-term children had similar geometric mean titer (GMT) values of
antibodies to tetanus, diphtheria, and pertussis. Preterm children had
a lower GMT value of Haemophilus polyribosylribitol
phosphate (PRP) antibody than did full-term children (0.99 vs 3.06 µg/mL). Fifty percent of preterm and 88% of full-term children had
PRP antibody >1.0 µg/mL; 100% of preterm and 94% of full-term
children had anti-PRP titers >0.15 µg/mL. GMT values of neutralizing
antibodies to polio serotypes 1 and 2 were similar, with 94% to 100%
of both groups above protective levels (
1:8). The difference in GMT
values of polio serotype 3 approached significance (29 vs 73); fewer preterm children had protective titer values (75% vs 100%). Among children vaccinated against hepatitis B, 75% of preterm and 71% of
full-term children were protected (10 mIU/mL).
Conclusions. Preterm children immunized at the recommended chronological ages displayed antibody responses similar to those for full-term children for most immunizing antigens. Responses to PRP and polio serotype 3 were less robust than those of full-term children.
Key words: immunization, polio vaccine, diphtheria-tetanus-pertussis vaccine, Haemophilus influenzae type b vaccine, hepatitis B vaccine.
CiteULike 
Connotea 
Del.icio.us 
Digg 
Facebook 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  J. S. Batra, E. M. Eriksen, K. M. Zangwill, M. Lee, S. M. Marcy, J. I. Ward, and for the Vaccine Safety Datalink Evaluation of Vaccine Coverage for Low Birth Weight Infants During the First Year of Life in a Large Managed Care Population Pediatrics, March 1, 2009; 123(3): 951 - 958. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Kaur, S. Chowdhury, N. S. Greenspan, and J. R. Schreiber Decreased expression of tumor necrosis factor family receptors involved in humoral immune responses in preterm neonates Blood, October 15, 2007; 110(8): 2948 - 2954. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Raqib, D. S Alam, P. Sarker, S. M. Ahmad, G. Ara, M. Yunus, S. E Moore, and G. Fuchs Low birth weight is associated with altered immune function in rural Bangladeshi children: a birth cohort study Am. J. Clinical Nutrition, March 1, 2007; 85(3): 845 - 852. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. T. D'Angio, P. A. Boohene, A. Mowrer, S. Audet, M. A. Menegus, D. S. Schmid, and J. A. Beeler Measles-Mumps-Rubella and Varicella Vaccine Responses in Extremely Preterm Infants Pediatrics, March 1, 2007; 119(3): e574 - e579. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Omenaca, J. Garcia-Sicilia, P. Garcia-Corbeira, R. Boceta, and V. Torres Antipolyribosyl Ribitol Phosphate Response of Premature Infants to Primary and Booster Vaccination With a Combined Diphtheria-Tetanus-Acellular Pertussis-Hepatitis B-Inactivated Polio Virus/Haemophilus influenzae Type b Vaccine Pediatrics, January 1, 2007; 119(1): e179 - e185. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J Bonhoeffer, C-A Siegrist, and P T Heath Immunisation of premature infants Arch. Dis. Child., November 1, 2006; 91(11): 929 - 935. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Omenaca, J. Garcia-Sicilia, P. Garcia-Corbeira, R. Boceta, A. Romero, G. Lopez, and R. Dal-Re Response of Preterm Newborns to Immunization With a Hexavalent Diphtheria-Tetanus-Acellular Pertussis-Hepatitis B Virus-Inactivated Polio and Haemophilus influenzae Type b Vaccine: First Experiences and Solutions to a Serious and Sensitive Issue Pediatrics, December 1, 2005; 116(6): 1292 - 1298. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. E. Baley and E. G. Leonard The Immunologic Basis for Neonatal Immunizations NeoReviews, October 1, 2005; 6(10): e463 - e470. [Full Text] [PDF]
|
|
|
|
|
|
M. J Robinson, C. Heal, E. Gardener, P. Powell, and D. G. Sims Antibody Response to Diphtheria-Tetanus-Pertussis Immunization in Preterm Infants Who Receive Dexamethasone for Chronic Lung Disease Pediatrics, April 1, 2004; 113(4): 733 - 737. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. N. Saari and and Committee on Infectious Diseases Immunization of Preterm and Low Birth Weight Infants Pediatrics, July 1, 2003; 112(1): 193 - 198. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P T Heath, R Booy, J McVernon, J Bowen-Morris, H Griffiths, M P E Slack, A C Moloney, M E Ramsay, and E R Moxon Hib vaccination in infants born prematurely Arch. Dis. Child., March 1, 2003; 88(3): 206 - 210. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. N. Nyambi, A. Nádas, H. A. Mbah, S. Burda, C. Williams, M. K. Gorny, and S. Zolla-Pazner Immunoreactivity of Intact Virions of Human Immunodeficiency Virus Type 1 (HIV-1) Reveals the Existence of Fewer HIV-1 Immunotypes than Genotypes J. Virol., November 15, 2000; 74(22): 10670 - 10680. [Abstract] [Full Text]
|
|
