This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by O'Shea, T. M.
Right arrow Articles by Dillard, R. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by O'Shea, T. M.
Right arrow Articles by Dillard, R. G.
Related Collections
Right arrow Premature & Newborn
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Facebook   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

PEDIATRICS Vol. 100 No. 6 December 1997, pp. 982-986

Survival and Developmental Disability in Infants With Birth Weights of 501 to 800 Grams, Born Between 1979 and 1994

Received Feb 5, 1997; accepted May 29, 1997.

T. Michael O'Shea, Kurt L. Klinepeter, Donald J. Goldstein, Barbara W. Jackson, and Robert G. Dillard

From the Department of Pediatrics, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, North Carolina.

Objective.  Because the survival rate has increased for extremely low birth weight neonates, many have raised the concern that the rate of developmental disability among survivors will also increase. To address this concern, we analyzed changes over time in survival and major neurosensory impairment in a sample of extremely low birth weight infants born between July 1, 1979, and June 30, 1994.

Methods.  The study sample included 513 infants with birth weights of 501 to 800 g who were cared for in either of the two neonatal intensive care units that serve a 17-county region in northwest North Carolina and who were born to mothers residing in that region. At 1 year of age (corrected for gestation), survivors were examined by a pediatrician and were tested using the Bayley Scales of Infant Development. Major neurosensory impairment was defined as cerebral palsy, a Bayley Mental Developmental Index <68, or blindness. A total of 209/216 (97%) of survivors were examined at 1 year of age. Epoch of birth was defined as follows: epoch 1, July 1, 1979 to June 30, 1984; epoch 2, July 1, 1984 to June 30, 1989; and epoch 3, July 1, 1989 to June 30, 1994.

Results.  Survival rates for epochs 1, 2, and 3 were, respectively, 24/120 (20%), 63/175 (36%), and 129/218 (59%). In contrast, the proportions with a major neurosensory impairment did not increase over time; rates for successive epochs were 6/24 (25%), 17/61 (28%), and 26/124 (21%). Rates of cerebral palsy were 3/24 (13%), 12/61 (20%), and 9/124 (7%); rates of delayed mental development were 4/24 (17%), 12/61 (20%), and 17/124 (14%); and rates of blindness were 2/24 (8%), 0/62, and 5/124 (4%), respectively.

Conclusions.  This analysis suggests that the increasing survival of extremely low birth weight neonates since the late 1970s has not resulted in an increased rate of major developmental problems identifiable at 1 year of age.

Key words: extremely low birth weight, prematurity, cerebral palsy, developmental outcome.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Facebook Facebook   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 PediatricsHome page
M. M. Bode, D. B. D'Eugenio, N. Forsyth, J. Coleman, C. R. Gross, and S. J. Gross
Outcome of Extreme Prematurity: A Prospective Comparison of 2 Regional Cohorts Born 20 Years Apart
Pediatrics, September 1, 2009; 124(3): 866 - 874.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
R. A. Gargus, B. R. Vohr, J. E. Tyson, P. High, R. D. Higgins, L. A. Wrage, and K. Poole
Unimpaired Outcomes for Extremely Low Birth Weight Infants at 18 to 22 Months
Pediatrics, July 1, 2009; 124(1): 112 - 121.
[Abstract] [Full Text] [PDF]

Home page
 Arch. Dis. Child. Fetal Neonatal Ed.Home page
M C Samaan, M Cuttini, V Casotto, and C A Ryan
Doctors' and nurses' attitudes towards neonatal ethical decision making in Ireland
Arch. Dis. Child. Fetal Neonatal Ed., May 1, 2008; 93(3): F217 - F221.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
W. Meadow, J. Lagatta, B. Andrews, L. Caldarelli, A. Keiser, J. Laporte, S. Plesha-Troyke, M. Subramanian, S. Wong, J. Hron, et al.
Just, in Time: Ethical Implications of Serial Predictions of Death and Morbidity for Ventilated Premature Infants
Pediatrics, April 1, 2008; 121(4): 732 - 740.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
R. Gray, S. Petrou, C. Hockley, and F. Gardner
Self-Reported Health Status and Health-Related Quality of Life of Teenagers Who Were Born Before 29 Weeks' Gestational Age
Pediatrics, July 1, 2007; 120(1): e86 - e93.
[Abstract] [Full Text] [PDF]

Home page
 Arch. Dis. Child. Fetal Neonatal Ed.Home page
J L Watts and S Saigal
Outcome of extreme prematurity: as information increases so do the dilemmas.
Arch. Dis. Child. Fetal Neonatal Ed., May 1, 2006; 91(3): F221 - F225.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
D. Wilson-Costello, H. Friedman, N. Minich, A. A. Fanaroff, and M. Hack
Improved Survival Rates With Increased Neurodevelopmental Disability for Extremely Low Birth Weight Infants in the 1990s
Pediatrics, April 1, 2005; 115(4): 997 - 1003.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
F. Blanco, G. Suresh, D. Howard, and R. F. Soll
Ensuring Accurate Knowledge of Prematurity Outcomes for Prenatal Counseling
Pediatrics, April 1, 2005; 115(4): e478 - e487.
[Abstract] [Full Text] [PDF]

Home page
 NeoReviewsHome page
R. J. Boyle
Ethical Issues in the Care of the Neonate: Overview
NeoReviews, November 1, 2004; 5(11): e471 - e476.
[Full Text] [PDF]

Home page
 PediatricsHome page
W. Meadow, G. Lee, K. Lin, and J. Lantos
Changes in Mortality for Extremely Low Birth Weight Infants in the 1990s: Implications for Treatment Decisions and Resource Use
Pediatrics, May 1, 2004; 113(5): 1223 - 1229.
[Abstract] [Full Text] [PDF]

Home page
 Arch. Dis. Child. Fetal Neonatal Ed.Home page
N Marlow
Neurocognitive outcome after very preterm birth
Arch. Dis. Child. Fetal Neonatal Ed., May 1, 2004; 89(3): F224 - F228.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
R. E. Hoekstra, T. B. Ferrara, R. J. Couser, N. R. Payne, and J. E. Connett
Survival and Long-Term Neurodevelopmental Outcome of Extremely Premature Infants Born at 23-26 Weeks' Gestational Age at a Tertiary Center
Pediatrics, January 1, 2004; 113(1): e1 - 6.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
S. Petrou, Z. Mehta, C. Hockley, P. Cook-Mozaffari, J. Henderson, and M. Goldacre
The Impact of Preterm Birth on Hospital Inpatient Admissions and Costs During the First 5 Years of Life
Pediatrics, December 1, 2003; 112(6): 1290 - 1297.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
M. Rijken, G. M. S. J. Stoelhorst, S. E. Martens, P. H. T. van Zwieten, R. Brand, J. Maarten Wit, and S. Veen
Mortality and Neurologic, Mental, and Psychomotor Development at 2 Years in Infants Born Less Than 27 Weeks' Gestation: The Leiden Follow-Up Project on Prematurity
Pediatrics, August 1, 2003; 112(2): 351 - 358.
[Abstract] [Full Text] [PDF]

Home page
 Arch. Dis. Child. Fetal Neonatal Ed.Home page
B A Darlow, A E Cust, and D A Donoghue
Improved outcomes for very low birthweight infants: evidence from New Zealand national population based data
Arch. Dis. Child. Fetal Neonatal Ed., January 1, 2003; 88(1): F23 - 28.
[Abstract] [Full Text] [PDF]

Home page
 Arch. Dis. Child. Fetal Neonatal Ed.Home page
V Tommiska, K Heinonen, P Kero, M-L Pokela, O Tammela, A-L Jarvenpaa, T Salokorpi, M Virtanen, V Fellman, and N Marlow
A national two year follow up study of extremely low birthweight infants born in 1996-1997
Arch. Dis. Child. Fetal Neonatal Ed., January 1, 2003; 88(1): F29 - 35.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
S. Winter, A. Autry, C. Boyle, and M. Yeargin-Allsopp
Trends in the Prevalence of Cerebral Palsy in a Population-Based Study
Pediatrics, December 1, 2002; 110(6): 1220 - 1225.
[Abstract] [Full Text] [PDF]

Home page
 Arch. Dis. Child. Fetal Neonatal Ed.Home page
V Tommiska, M Ostberg, and V Fellman
Parental stress in families of 2 year old extremely low birthweight infants
Arch. Dis. Child. Fetal Neonatal Ed., May 1, 2002; 86(3): F161 - F164.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
D. K. Richardson
A Woman With an Extremely Premature Newborn
JAMA, September 26, 2001; 286(12): 1498 - 1505.
[Full Text] [PDF]

Home page
 J Child NeurolHome page
M. N. Nelson, R. C. White-Traut, U. Vasan, J. Silvestri, E. Comiskey, P. Meleedy-Rey, S. Littau, Guoguang Gu, and M. Patel
One-Year Outcome of Auditory-Tactile-Visual-Vestibular Intervention in the Neonatal Intensive Care Unit: Effects of Severe Prematurity and Central Nervous System Injury
J Child Neurol, July 1, 2001; 16(7): 493 - 498.
[Abstract] [PDF]

Home page
 PediatricsHome page
M. Subhani, A. Combs, P. Weber, C. Gerontis, and J. D. DeCristofaro
Screening Guidelines for Retinopathy of Prematurity: The Need for Revision in Extremely Low Birth Weight Infants
Pediatrics, April 1, 2001; 107(4): 656 - 659.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
V. Tommiska, K. Heinonen, S. Ikonen, P. Kero, M.-L. Pokela, M. Renlund, M. Virtanen, and V. Fellman
A National Short-Term Follow-Up Study of Extremely Low Birth Weight Infants Born in Finland in 1996-1997
Pediatrics, January 1, 2001; 107(1): 2e - 2.
[Abstract] [Full Text]

Home page
 PediatricsHome page
K. Costeloe, E. Hennessy, A. T. Gibson, N. Marlow, A. R. Wilkinson, and for the EPICure Study Group
The EPICure Study: Outcomes to Discharge From Hospital for Infants Born at the Threshold of Viability
Pediatrics, October 1, 2000; 106(4): 659 - 671.
[Abstract] [Full Text]

Home page
 PediatricsHome page
S. B. Morse, J. L. Haywood, R. L. Goldenberg, J. Bronstein, K. G. Nelson, and W. A. Carlo
Estimation of Neonatal Outcome and Perinatal Therapy Use
Pediatrics, May 1, 2000; 105(5): 1046 - 1050.
[Abstract] [Full Text]

Home page
 Nurs EthicsHome page
B. S. Brinchmann
'They have to Show that they can Make it': Vitality as a Criterion for the Prognosis of Premature Infants
Nursing Ethics, March 1, 2000; 7(2): 141 - 147.
[Abstract] [PDF]

Home page
 Evid. Based Nurs.Home page
Other Articles Noted
Evid. Based Nurs., October 1, 1998; 1(4): 100 - 104.
[Full Text]

Home page
 Topics in Early Childhood Special EducationHome page
T. C. McNab and J. A. Blackman
Medical Complications of the Critically III Newborn: A Review for Early Intervention Professionals
Topics in Early Childhood Special Education, January 1, 1998; 18(4): 197 - 205.
[Abstract] [PDF]