This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lesko, S. M.
Right arrow Articles by Mitchell, A. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lesko, S. M.
Right arrow Articles by Mitchell, A. A.
Related Collections
Right arrow Therapeutics & Toxicology
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Facebook   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

PEDIATRICS Vol. 100 No. 6 December 1997, pp. 954-957

Renal Function After Short-term Ibuprofen Use in Infants and Children

Received Mar 25, 1997; accepted May 12, 1997.

Samuel M. Lesko and Allen A. Mitchell

From the Slone Epidemiology Unit, School of Public Health, Boston University School of Medicine, Brookline, Massachusetts.

Objective.  To test the hypothesis that short-term use of ibuprofen increases the risk of impaired renal function in children.

Study Design.  Randomized, double-blind acetaminophen-controlled clinical trial. Children with a febrile illness were enrolled from outpatient pediatric and family medicine practices and randomly assigned to receive either acetaminophen suspension or one of two dosages of ibuprofen suspension (5 mg/kg or 10 mg/kg) for fever control.

Results.  Mean blood urea nitrogen levels on admission among children admitted to hospital and assigned ibuprofen 5 mg/kg (n = 96), ibuprofen 10 mg/kg (n = 102), and acetaminophen 12 mg/kg (n = 87) were 4.1, 3.8, and 3.9 mmol/L, respectively. The corresponding creatinine levels were 43, 41, and 43 µmol/L, respectively. The prevalence of a creatinine level >62 µmol/L was 9.5% overall and did not vary by antipyretic assignment. Among 83 children hospitalized with dehydration, the mean creatinine level was 44 µmol/L, and the prevalence of an elevated creatinine was 14%; neither measure varied by antipyretic assignment.

Conclusion.  Although renal failure in children has been reported after ibuprofen use, these data suggest that for short-term use the risk of less severe renal impairment, as reflected by blood urea nitrogen and creatinine levels, is small and not significantly greater than that after acetaminophen use.

Key words: ibuprofen, nonsteroidal antiinflammatory drugs, acetaminophen, renal function, blood urea nitrogen, creatinine, clinical trial.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Facebook Facebook   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 CLIN PEDIATRHome page
L. C. Kramer, P. A. Richards, A. M. Thompson, D. P. Harper, and M. P. Fairchok
Alternating Antipyretics: Antipyretic Efficacy of Acetaminophen Versus Acetaminophen Alternated With Ibuprofen in Children
Clinical Pediatrics, November 1, 2008; 47(9): 907 - 911.
[Abstract] [PDF]

Home page
 Arch Pediatr Adolesc MedHome page
E. M. Sarrell, E. Wielunsky, and H. A. Cohen
Antipyretic Treatment in Young Children With Fever: Acetaminophen, Ibuprofen, or Both Alternating in a Randomized, Double-blind Study
Arch Pediatr Adolesc Med, February 1, 2006; 160(2): 197 - 202.
[Abstract] [Full Text] [PDF]

Home page
 Journal of Pharmacy PracticeHome page
P. C. Walker and D. S. Wagner
Treatment of Pain in Pediatric Patients
Journal of Pharmacy Practice, August 1, 2003; 16(4): 261 - 275.
[Abstract] [PDF]

Home page
 PediatricsHome page
S. M. Lesko and A. A. Mitchell
The Safety of Acetaminophen and Ibuprofen Among Children Younger Than Two Years Old
Pediatrics, October 1, 1999; 104(4): 39e - 39.
[Abstract] [Full Text]