This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Berhane, R.
Right arrow Articles by Olness, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Berhane, R.
Right arrow Articles by Olness, K.
Related Collections
Right arrow Infectious Disease & Immunity

PEDIATRICS Vol. 100 No. 1 July 1997, p. e7
Copyright ©1997 by the American Academy of Pediatrics

ELECTRONIC ARTICLE:
Growth Failure as a Prognostic Indicator of Mortality in Pediatric HIV Infection

Received May 8, 1996; accepted Oct 28, 1996.

Rahel Berhane*, Danstan BagendaDagger , Lawrence Marum§, Esther Aceng, Christopher Ndugwa, Ronald J Boschpar , and Karen Olness§

From the * New England Medical Center, Tufts University, Boston Massachusetts; the Dagger  Human Reproductive Research Unit, Department of Obstetrics and Gynaecology, Makerere University, Kampala, Uganda; the § Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio; the  Department of Paediatrics and Child Health, Makerere University, Kampala, Uganda; and the par  Harvard School of Public Health, Boston, Massachusetts.

Objective.  To study the effect of perinatally acquired human immunodeficiency virus (HIV) on somatic growth and examine the relationship of nutritional status to mortality in HIV-infected infants.

Method.  Pregnant women attending the antenatal clinic at Mulago hospital in Kampala, Uganda, were enrolled. All live-born babies born to HIV-1 seropositive (HIV+) women, and to every fourth age-matched HIV-1 seronegative (HIV-) woman, were followed for 25 months.

Results.  The mean weight-for-age and length-for-age curves of HIV+ children were significantly lower than those of HIV- controls and seroeverters. Forty-five (54%) of the 84 HIV+ infants died before their second birthday, as compared with a 1.6% and 5.6% mortality in HIV- and seroeverters. HIV+ infants with an average weight-for-age Z-score below -1.5 in the first year of life have a nearly fivefold risk of dying before 25 months of age compared with noninfected controls.

Conclusion.  Perinatally acquired HIV infection is associated with early and progressive growth failure. The severity of growth failure is associated with an increased risk of mortality. The effect of early, aggressive nutritional intervention in delaying HIV progression and mortality should be evaluated by controlled intervention studies.

Key words: HIV-1, mortality, weight-for-age Z-score, height for age Z-score.




This article has been cited by other articles:


Home page
 Journal of Health Politics, Policy and LawHome page
J. B. Wolf
Is Breast Really Best? Risk and Total Motherhood in the National Breastfeeding Awareness Campaign
Journal of Health Politics Policy and Law, August 1, 2007; 32(4): 595 - 636.
[Abstract] [PDF]

Home page
 Journal of Health Politics, Policy and LawHome page
J. M. Hopkinson
Response to "Is Breast Really Best? Risk and Total Motherhood in the National Breast-Feeding Awareness Campaign"
Journal of Health Politics Policy and Law, August 1, 2007; 32(4): 637 - 648.
[PDF]

Home page
 Sex AbuseHome page
C. Kjellgren, A. Wassberg, M. Carlberg, N. LAngstrom, and C. Goran Svedin
Adolescent Sexual Offenders: A Total Survey of Referrals To Social Services in Sweden and Subgroup Characteristics
Sexual Abuse: A Journal of Research and Treatment, October 1, 2006; 18(4): 357 - 372.
[Abstract] [PDF]

Home page
 Arch. Dis. Child. Fetal Neonatal Ed.Home page
O Flidel-Rimon and E S Shinwell
Breast feeding twins and high multiples.
Arch. Dis. Child. Fetal Neonatal Ed., September 1, 2006; 91(5): F377 - F380.
[Abstract] [Full Text] [PDF]

Home page
 Journal of Early InterventionHome page
C. C. Robinson and S. A. Rosenberg
Child Welfare Referrals to Part C
Journal of Early Intervention, July 1, 2004; 26(4): 284 - 291.
[Abstract] [PDF]

Home page
 J. Nutr.Home page
S. M. Arpadi, P. A. Cuff, D. P. Kotler, J. Wang, M. Bamji, M. Lange, R. N. Pierson, and D. E. Matthews
Growth Velocity, Fat-Free Mass and Energy Intake Are Inversely Related to Viral Load in HIV-Infected Children
J. Nutr., October 1, 2000; 130(10): 2498 - 2502.
[Abstract] [Full Text]