This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kato, S.
Right arrow Articles by Naganuma, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kato, S.
Right arrow Articles by Naganuma, H.
Related Collections
Right arrow Gastrointestinal Tract

PEDIATRICS Vol. 100 No. 1 July 1997, p. e3
Copyright ©1997 by the American Academy of Pediatrics

ELECTRONIC ARTICLE:
Omeprazole-based Dual and Triple Regimens for Helicobacter pylori Eradication in Children

Received Sep 6, 1996; accepted Dec 12, 1996.

Seiichi Kato*, Junji Takeyama*, Kyoko Ebina*, and Hiroshi NaganumaDagger

From the Departments of * Pediatrics and Dagger  Pathology, Sendai City Hospital, Sendai, Japan.

Objective.  To evaluate the efficacy and safety of omeprazole-based dual and triple regimens for the treatment of children with Helicobacter pylori infection.

Methods.  Twenty-two patients (3 with gastric ulcer, 12 with duodenal ulcer, and 7 with nodular gastritis alone) were studied. Twelve ulcer patients also had nodular gastritis. The dual regimen included a 2-week course of omeprazole (0.6 mg/kg twice a day) and amoxicillin (30 mg/kg twice a day) (n = 10), and the triple regimen included the dual regimen plus clarithromycin (15 mg/kg twice a day) (n = 12). In patients with active ulcers, omeprazole once daily was administered for another 4 weeks. Endoscopic biopsies were taken before therapy and 4 weeks after completion of a 2-week course of therapy, and patients were followed for 6 months. The gastritis score (grade 0 to 3) and serum anti-H pylori IgG antibody titers were also determined.

Results.  The regimens were tolerated by all patients. Eradication rates for the dual and triple regimens were 70% and 92%, respectively. Active ulcers completely healed within 6 weeks. Patients with nodular gastritis alone showed different clinical responses to therapy. Pretreatment histology showed chronic gastritis in all patients. Successful H pylori eradication significantly reduced the mean gastritis score from 2.9 to 1.3, but unsuccessful eradication did not reduce it. The disappearance of antral nodularity often coincided with the success of eradication. Successful eradication significantly decreased pretreatment serum anti-H pylori IgG antibody titers by 29% at 1 month, by 52% at 3 months, and by 67% at 6 months. Side effects were mild and were reported in 23% of patients.

Conclusion.  An omeprazole-based regimen is safe and may be a better option for eradication of H pylori in children. Antral nodularity is a macroscopic marker of H pylori infection.

Key words: Helicobacter pylori, gastritis, omeprazole, amoxicillin, clarithromycin.




This article has been cited by other articles:


Home page
 NeoReviewsHome page
B. A. Banks
Postnatal Dexamethasone for Bronchopulmonary Dysplasia: A Systematic Review and Meta-analysis of 20 Years of Clinical Trials
NeoReviews, February 1, 2002; 3(2): e24 - 34.
[Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
P. L. RAMSAY, F. J. DeMAYO, S. E. HEGEMIER, M. E. WEARDEN, C. V. SMITH, and S. E. WELTY
Clara Cell Secretory Protein Oxidation and Expression in Premature Infants Who Develop Bronchopulmonary Dysplasia
Am. J. Respir. Crit. Care Med., July 1, 2001; 164(1): 155 - 161.
[Abstract] [Full Text] [PDF]

Home page
 Arch. Dis. Child. Fetal Neonatal Ed.Home page
E S Shinwell, M Karplus, D Reich, Z Weintraub, S Blazer, D Bader, S Yurman, T Dolfin, A Kogan, S Dollberg, et al.
Early postnatal dexamethasone treatment and increased incidence of cerebral palsy
Arch. Dis. Child. Fetal Neonatal Ed., November 1, 2000; 83(3): 177F - 181.
[Abstract] [Full Text]

Home page
 Arch. Dis. Child. Fetal Neonatal Ed.Home page
T F Fok, K Lam, M Dolovich, P C Ng, W Wong, K L Cheung, and K W So
Randomised controlled study of early use of inhaled corticosteroid in preterm infants with respiratory distress syndrome
Arch. Dis. Child. Fetal Neonatal Ed., May 1, 1999; 80(3): 203F - 208.
[Abstract] [Full Text]