PEDIATRICS Vol. 10 No. 6 December 1952, pp. 660-666
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OXALOSIS

Possible "Inborn Error of Metabolism" with Nephrolithiasis and Nephrocalcinosis Due to Calcium Oxalate as the Predominating Features

L. YING CHOU M.D.1 and W. L. DONOHUE M.D.2

1 The Department of Pathology, The Hospital for Sick Children, Toronto, and the Department of Pathology, Faculty of Medicine, The University of Toronto., The Department of Pediatrics, Faculty of Medicine, the University of British Columbia, Vancouver, B.C.
2 The Department of Pathology, The Hospital for Sick Children, Toronto, and the Department of Pathology, Faculty of Medicine, The University of Toronto.

A case is reported of renal failure in a boy subsequent to recurrent calcium oxalate urinary calculi. The post mortem disclosed widespread deposits in the tissues of calcium oxalate crystals. These were particularly prominent in the kidneys and bone marrow.

It is suggested that this is the end result of an "inborn error of metabolism" in which there was an excessive formation of oxalic acid.

Submitted on August 1, 1952