PEDIATRICS Vol. 10 No. 5 November 1952, pp. 593-602
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PRESSURE-TIME RELATIONS IN THE SAFE CORRECTION OF ATELECTASIS IN ANIMAL LUNGS

RICHARD DAY M.D.1, ALICE M. GOODFELLOW M.D.1, VIRGINIA APGAR M.D.1, and GUSTAV J. BECK M.D.1

1 The Departments of Pediatrics, Anesthesiology and Medicine, College of Physicians and Surgeons, Columbia University, New York City.

Observations on animal lungs have been made which support the following statements: Injury to lungs is caused by overdistention.

Distention is related to time as well as to the pressure exerted.

A certain minimum pressure must be exerted to correct atelectasis. To employ this pressure safely, its duration must be limited.

The combinations of pressure and time which produce satisfactory inflation in rat, rabbit and pig lungs are very similar to each other. Research is needed to find the combinations which are utilized by the normal newborn infant and which might be suitable in positive pressure resuscitation.

No practical application has so far been attempted of the methods of inflation which have been described. Small differences in the duration of each positive pressure inflation determine the safety of the procedure. Clinical application is a subject for future research.

Submitted on June 27, 1952




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