PEDIATRICS Vol. 10 No. 4 October 1952, pp. 450-456
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STUDIES OF THE IMMUNOLOGY OF THE NEWBORN INFANT

III. Permeability of the Placenta to Maternal Antibody During Fetal Life

JOHN J. OSBORN M.D.1, JOSEPH DANCIS M.D.1, and BLANCHE V. ROSENBERG B.A.1

1 The Department of Pediatrics, New York University College of Medicine, New York City.

The titer of diphtheria antitoxin in maternal and infant (cord) blood was compared in 56 premature infants. A significant correlation was found between birth weight and placental permeability to diphtheria antitoxin. Small premature infants (under 1200 gm.) have much less circulating antitoxin derived from the mother than do larger premature infants. In 10 premature infants with high cord titers of diphtheria antitoxin, this passive immunity was lost at about the same rate as by normal newborn infants.

Submitted on January 7, 1952