PEDIATRICS Vol. 10 No. 4 October 1952, pp. 381-396
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STUDIES ON THE METABOLISM AND DISPOSAL OF AMINO ACID MIXTURES GIVEN INTRAVENOUSLY

WILLIAM M. MULHOLLAND 1, EDWARD M. BRIDGE 1, and HELEN W. FOX 1

1 The Department of Pediatrics of the University of Buffalo School of Medicine and the Statler Research Laboratories of the Children's Hospital of Buffalo.

The effects of continuous eight hour infusions of casein hydrolysate have been studied in normal fasting rabbits. At a rate of 1.0 gm. hydrolysate/kg./hr., approximately 5% of the infused material is lost directly into the urine as amino nitrogen. Another 1 to 2% remains in the blood stream during the infusions but is quickly dissipated when the injection is discontinued.

Deamination, as indicated by the accumulation and excretion of urea, increases steadily and proceeds at a rapid rate for approximately four hours after the infusion is discontinued. In all, 60 to 70% of the infused material may appear in the urine as urea, and another 10 to 20% in other forms. A relatively small amount is available for tissue use beyond four hours after the end of the administration.

Although retention of nitrogenous metabolites occurs during infusions at this rate and persists for several hours afterward, renal function is not impaired.

The respiratory quotient during continuous eight hour infusions was found to fall to the level of 0.72 to 0.74. The significance of this is uncertain.

It is suggested that relatively small amounts of complete amino acid mixtures administered continuously might supply the tissues more efficiently than when much larger amounts are given intermittently.

Submitted on December 7, 1951




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[Abstract] [Full Text]