PEDIATRICS Vol. 10 No. 3 September 1952, pp. 243-252
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by HSIA, D. Y.-Y.
Right arrow Articles by GELLIS, S. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by HSIA, D. Y.-Y.
Right arrow Articles by GELLIS, S. S.

PROLONGED OBSTRUCTIVE JAUNDICE IN INFANCY

1. General Survey of 156 Cases

DAVID YI-YUNG HSIA M.D.1, PAUL PATTERSON M.D.1, FRED H. ALLEN JR. M.D.1, LOUIS K. DIAMOND M.D.1, and SYDNEY S. GELLIS M.D.1

1 The Medical Service and Blood Grouping Laboratory of the Children's Medical Center, the Department of Pediatrics of the Beth Israel Hospital, and the Department of Pediatrics, Harvard Medical School, Boston.

One hundred fifty-six cases of prolonged obstructive jaundice seen at the Children's Medical Center between 1940 and 1951 have been investigated and in 85% of the patients follow-up studies have been carried out.

Ninety-four (61%) were due to true biliary atresia.

Twenty-three (15%) were due to inspissated bile associated with erythroblastosis. All these patients are living and well and free of jaundice. The diagnosis of this condition can be made when the patient has (1) jaundice during the first two days of life with persistence of jaundice for over three weeks, (2) a high direct and indirect bilirubin compatible with obstructive jaundice, (3) negative flocculation tests, (4) blood-grouping studies consistent with erythroblastosis.

Thirty (19%) were due to inspissated bile of unknown etiology. Of these 6 are dead, 2 are alive but cirrhotic, and 18 are living and well and no follow-up was obtained on the four other cases. There appears to be some relationship between this condition and immaturity of the liver, small extrahepatic ducts, thickened secretions, and possibly dehydration.

Nine (6%) were due to miscellaneous causes, of which four cases were probably due to infectious hepatitis.

Submitted on April 4, 1952